This week offers some compelling matchups in the Top 25 ranks and we have two of them before Saturday even gets here. There are two terrific Friday night games to kick off Week 5 with 14th-ranked Miami heading to Duke and 5th-ranked USC traveling to the Palouse to take on upstart Washington State. Saturday night’s ABC game was Clemson taking on Virginia Tech in what should be a great game. Check back often as we update our picks all week. We will have our Top 25 Free Picks against the spread all year and our NFL Staff Selections.
| DATE – TIME ET | WEEK 2 GAMES | JAY COOPER (48-39-2) |
| 9/29 – 7:00 | 14 Miami FL @ Duke | Duke +7 (L) |
| 9/29 – 10:30 | 5 USC @ 16 Washington State | Washington State +3.5 (W) |
| 9/30 – Noon | Northwestern @ 10 Wisconsin | Wisconsin -15 (L) |
| 9/30 – Noon | Vanderbilt @ 21 Florida | Florida -10 (W) |
| 9/30 – Noon | 18 South Florida @ East Carolina | South Florida -23 (W) |
| 9/30 – 3:30 | Murray State @ 17 Louisville | OFF |
| 9/30 – 3:30 | 7 Georgia @ Tennessee | Georgia -8 (W) |
| 9/30 – 3:30 | Indiana @ 4 Penn State | Indiana +18 (L) |
| 9/30 – 5:00 | Miami OH @ 22 Notre Dame | Notre Dame -21 (W) |
| 9/30 – 6:00 | 24 Mississippi State @ 13 Auburn | Mississippi State +8 (L) |
| 9/30 – 7:30 | 11 Ohio State @ Rutgers | Ohio State -30 (W) |
| 9/30 – 8:00 | 15 Oklahoma State @ Texas Tech | Texas Tech +10.5 (W) |
| 9/30 – 8:00 | 6 Washington @ Oregon State | Washington -26.5 (W) |
| 9/30 – 8:00 | 2 Clemson @ 12 Virginia Tech | Virginia Tech +7.5 (L) |
| 9/30 – 9:00 | Ole Miss @ 1 Alabama | Alabama -27.5 (W) |
| 9/30 – 10:30 | Northern Illinois @ 19 San Diego State | San Diego State -11 (L) |
