Seattle (2-1) at Arizona (2-1)
When: Thursday, September 25th 2025
Where: State Farm Stadium,
Glendale, AZ
Time: 8:15 ET | TV: Prime
Opening Odds: Arizona -2.5/45
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Seahawks vs Cardinals Recent Meetings
| Date | Away/Home | Line | ATS | Tot | Rus | Pas | Tot | Rus | Pas |
|---|---|---|---|---|---|---|---|---|---|
| 12/8/24 | SEA (30) - ARI (18) | -3/46 | SEA/O | 409 | 176 | 233 | 356 | 121 | 235 |
| 11/24/24 | ARI (6) - SEA (16) | 1/46.5 | SEA/U | 285 | 65 | 220 | 298 | 49 | 249 |
| 1/7/24 | SEA (21) - ARI (20) | 3/48 | ARI/U | 327 | 138 | 189 | 466 | 206 | 260 |
| 10/22/23 | ARI (10) - SEA (20) | -10/43.5 | P/U | 318 | 115 | 203 | 249 | 127 | 122 |
| 11/6/22 | SEA (31) - ARI (21) | -2.5/49 | SEA/O | 421 | 158 | 263 | 262 | 122 | 140 |
| 10/16/22 | ARI (9) - SEA (19) | 2.5/50.5 | SEA/U | 296 | 136 | 160 | 315 | 144 | 171 |
| 1/9/22 | SEA (38) - ARI (30) | -5.5/49 | SEA/O | 431 | 202 | 229 | 305 | 118 | 187 |
| 11/21/21 | ARI (23) - SEA (13) | -4.5/44.5 | ARI/U | 266 | 86 | 180 | 413 | 95 | 318 |
| 11/19/20 | ARI (21) - SEA (28) | -3/56.5 | SEA/U | 347 | 165 | 182 | 314 | 57 | 257 |
| 10/25/20 | SEA (34) - ARI (37) | 3.5/55.5 | ARI/O | 572 | 200 | 372 | 519 | 159 | 360 |
Seahawks Injury Report
| Player | Status/Updated | |
|---|---|---|
| Robbie Ouzts | FB | Ques Sept. 25 - Ankle - 9/23/25 |
| Boye Mafe | LB | Ques Sept. 25 - Toe - 9/23/25 |
| Elijah Arroyo | TE | Ques Sept. 25 - Groin - 9/23/25 |
| Leonard Williams | DE | Ques Sept. 25 - Elbow - 9/23/25 |
| Jalen Sundell | C | Ques Sept. 25 - Ankle - 9/23/25 |
| Josh Jones | G | Ques Sept. 25 - Ankle - 9/23/25 |
| Zach Charbonnet | RB | Ques Sept 25 - Foot - 9/21/25 |
| Julian Love | S | Ques Sept. 25 - Hamstring - 9/21/25 |
| Devon Witherspoon | CB | Ques Sept. 25 - Knee - 9/21/25 |
| Anthony Bradford | G | Ques Sept. 25 - Back - 9/21/25 |
| Jake Bobo | WR | Ques Sept. 25 - Concussion - 9/21/25 |
| Olu Oluwatimi | C | Ques Sept. 25 - Back - 9/21/25 |
| Charles Cross | OT | Ques Sept. 25 - Finger - 9/21/25 |
| Kenny McIntosh | RB | Ques Sept. 25 - Leg - 9/21/25 |
| Nick Emmanwori | S | Out indefinitely - Ankle - 9/9/25 |
| Christian Haynes | G | Out indefinitely - Pectoral - 8/28/25 |
| AJ Finley | S | Out indefinitely - Knee - 8/5/25 |
| Johnathan Hankins | DT | Out indefinitely - Back - 8/28/25 |
| Rylie Mills | DE | Out indefinitely - Knee - 8/28/25 |
Cardinals Injury Report
| Player | Status/Updated | |
|---|---|---|
| Zay Jones | WR | Ques Sept. 25 - Concussion - 9/23/25 |
| Evan Brown | OL | Ques Sept. 25 - Ankle - 9/23/25 |
| Darren Hall | CB | Ques Sept. 25 - Ankle - 9/23/25 |
| Akeem Davis-Gaither | LB | Ques Sept. 25 - Elbow - 9/23/25 |
| Paris Johnson Jr. | OL | Ques Sept. 25 - Knee - 9/22/25 |
| Will Johnson | CB | Ques Sept. 25 - Groin - 9/21/25 |
| Sean Murphy-Bunting | CB | Ques Sept. 25 - Knee - 9/21/25 |
| Elijah Jones | CB | Ques Sept. 25 - Ankle - 9/21/25 |
| James Conner | RB | Out Sept. 25 - Foot - 9/23/25 |
| L.J. Collier | DL | Out indefinitely - Knee - 9/17/25 |
| Garrett Williams | CB | Out indefinitely - Knee - 9/17/25 |
| Justin Jones | DL | Out indefinitely - Knee - 8/28/25 |
| Hayden Conner | OL | Out indefinitely - Knee - 8/27/25 |
| Christian Jones | OT | Out indefinitely - Knee - 8/27/25 |
| Trishton Jackson | WR | Out indefinitely - Thumb - 8/12/25 |
| Will Hernandez | G | Ques Sept. 25 - Knee - 9/22/25 |
| Valentin Senn | OL | Out indefinitely - Undisclosed - 8/4/25 |
| Joey Blount | S | out for season - Neck - 9/10/25 |
| Starling Thomas V | CB | Out indefinitely - Knee - 7/27/25 |
| J.J. Russell | LB | out for season - Head - 8/27/25 |
| Bilal Nichols | DT | Out indefinitely - Neck - 7/24/25 |
| Walter Nolen III | DT | Out indefinitely - Calf - 7/24/25 |
| BJ Ojulari | LB | Out indefinitely - Knee - 7/24/25 |
Prediction
I really like Seattle in this one. After sputtering in Week 1 against San Francisco, this team has found its stride. Sam Darnold turned in his best performance yet in last week’s dominating win over the Saints. Meanwhile, the defense has held opponents to just 15.7 points per game. Arizona’s offense has been terrible, scoring fewer than 20 points in two of three games and Kyler Murray is averaging just 180 passing yards per game. The Seahawks have won seven straight over Arizona, including two double-digit victories last year in which the Cardinals managed only 24 total points. Make it eight in a row.
Pick: Seahawks PK
