Carolina (6-5) at San Francisco (7-4)
When: Monday, November 24th 2025
Where: Levi’s Stadium,
Santa Clara, CA
Time: 8:15 ET | TV: ESPN
Opening Odds: San Francisco -6/45.5
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Panthers vs 49ers Recent Meetings
Prediction
Carolina is playing in just their third Monday night game since 2018 and come into this contest playing well. Bryce Young has been one of the best quarterbacks versus the spread this season and is 7-2 ATS over his last nine starts. Carolina has also covered five of six games versus the NFC and have covered four of their last five road contests. San Francisco ranks dead last in defensive sacks and also have the second-fewest interceptions. At home, the 49ers have eight giveaways, one takeaway, and are on a 1-5 ATS run. The Panthers are a good young team playing a defense that is struggling. Give me the points.
Pick: Panthers +7
