Michigan (4-1) at USC (4-1)
When: Saturday, October 11th 2025
Where: L.A. Coliseum,
Los Angeles, CA
Time: 7:30 ET | TV: NBC
Opening Odds: USC -2.5/55.5
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Michigan Season Results
| Date | Week | vs | Score |
|---|---|---|---|
| Saturday, October 4, 2025 | Week 6 | Wisconsin | W 24-10 |
| Saturday, September 20, 2025 | Week 4 | @ Nebraska | W 30-27 |
| Saturday, September 13, 2025 | Week 3 | Central Michigan | W 63-3 |
| Saturday, September 6, 2025 | Week 2 | @ Oklahoma | L 13-24 |
| Saturday, August 30, 2025 | Week 1 | New Mexico | W 34-17 |
USC Season Results
| Date | Week | vs | Score |
|---|---|---|---|
| Saturday, September 27, 2025 | Week 5 | @ Illinois | L 32-34 |
| Saturday, September 20, 2025 | Week 4 | Michigan State | W 45-31 |
| Saturday, September 13, 2025 | Week 3 | @ Purdue | W 33-17 |
| Saturday, September 6, 2025 | Week 2 | Georgia Southern | W 59-20 |
| Saturday, August 30, 2025 | Week 1 | Missouri State | W 73-13 |
Prediction
USC has talented wide receivers that will give Michigan some trouble, but the Trojans offensive line is an issue. The Wolverines will get pressure and cause mistakes and turnovers. Michigan just has more talent overall and the running game will give USC fits. Also, Lincoln Riley has had trouble winning big games. It will be close, but Michigan ultimately finds a way to win.
Pick: Michigan +2.5
