Lions vs Ravens Odds and Free Prediction [9/22/25]

Detroit (1-1) at Baltimore (1-1)
When: Monday, September 22nd 2025
Where: M&T Bank Stadium,
Baltimore, MD

Time: 8:15 ET | TV: ESPN
Opening Odds: Baltimore -6.5/50.5

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Lions vs Ravens Recent Meetings

DateAway/HomeLineATSTotRusPasTotRusPas
10/22/23DET (6) - BAL (38)-3/43.5BAL/O33784253503146357
9/26/21BAL (19) - DET (17)7.5/51DET/U28593192387116271
12/3/17DET (20) - BAL (44)-2.5/43BAL/O37278294370101269
8/27/16DET (9) - BAL (30)-2.5/42BAL/U226101125363134229
12/16/13BAL (18) - DET (16)-4.5/49BAL/U34911923030590215
8/17/12DET (27) - BAL (12)-3/39.5DET/U507166341343122221
12/13/09DET (3) - BAL (48)-14/40.5BAL/O229103126548308240
10/9/05BAL (17) - DET (35)-1.5/33DET/O26616997387159228
8/28/04DET (6) - BAL (17)-3.5/33.5BAL/U23973166348164184
8/9/02DET (6) - BAL (12)-3/33BAL/U000000
Courtesy of Don Best Sports

Lions Injury Report

Player Status/Updated
Kerby JosephSQues Sept. 22 - Knee - 9/18/25
D.J. ReedCBQues Sept. 22 - Knee - 9/18/25
Jack CampbellLBQues Sept. 22 - Ankle - 9/18/25
Marcus DavenportDEQues Sept. 22 - Ankle - 9/14/25
Kayode AwosikaGQues Sept. 22 - Shoulder - 9/14/25
Trevor NowaskeLBQues Sept. 22 - Elbow - 9/14/25
Graham GlasgowOLQues Sept. 22 - Leg - 9/14/25
Dominic LovettWRQues Sept. 22 - Abdominal - 9/14/25
Sione VakiRBQues Sept. 22 - Hamstring - 9/14/25
Miles FrazierGQues Sept. 22 - Undisclosed - 9/14/25
Malcolm RodriguezLBQues Sept. 22 - Knee - 9/14/25
Taylor DeckerOTQues Sept 22 - Undisclosed - 9/18/25
Levi OnwuzurikeDLOut For Season - Knee - 7/21/25
Shane ZylstraTEOut indefinitely - Ankle - 9/17/25
Ezekiel TurnerLBout for season - Foot - 8/28/25
Justin HerronOTout for season - Undisclosed - 8/11/25
Colby SorsdalOLout for season - Undisclosed - 8/11/25
Jamarco JonesOTout for season - Ankle - 9/8/25
Dan JacksonSOut indefinitely - Leg - 8/5/25
Kenny YeboahTEout for season - Leg - 8/11/25
Alim McNeillDLOut indefinitely - Knee - 7/24/25
Ennis Rakestraw Jr.CBOut Indefinitely - Shoulder - 8/8/25
Josh PaschalDEOut indefinitely - Undisclosed - 7/24/25
Courtesy of Don Best Sports

Ravens Injury Report

Player Status/Updated
Nate WigginsCBQues Sept 22 - Groin - 9/18/25
Marlon HumphreyCBQues Sept. 22 - Groin - 9/14/25
Daniel FaaleleGQues Sept. 22 - Illness - 9/14/25
Keaton MitchellRBQues Sept. 22 - Hamstring - 9/14/25
Nnamdi MadubuikeDLOut Sept. 22 - Neck - 9/20/25
Kyle Van NoyLBOut indefinitely - Hamstring - 9/15/25
Patrick RicardFBOut Sept. 22 - Calf - 9/20/25
Isaiah LikelyTEOut Sept. 22 - Foot - 9/20/25
Adisa IsaacLBOut indefinitely - Elbow - 8/27/25
Dayton WadeWROut indefinitely - Ribs - 8/27/25
Robert LongerbeamCBout for season - Undisclosed - 8/11/25
Emery Jones Jr.OTOut indefinitely - Shoulder - 9/8/25
Bilhal KoneCBOut indefinitely - Knee - 8/9/25
Ar'Darius WashingtonSOut indefinitely - Achilles - 7/24/25
Courtesy of Don Best Sports


Prediction

After a dud in Week 1, the Lions woke up and dominated the Bears in Week 2. People seem to be down on Detroit this year, but I wouldn’t sleep on them. Baltimore rolled Cleveland last week after handing the Bills the game in Week 1. The Ravens inability to close out games has been a problem for several years now. Baltimore will be without standout defensive tackle Nnamdi Madubuike and veteran linebacker Kyle Van Noy (hamstring). Lamar Jackson has been great on Monday nights, but Jared Goff will find a way to keep this close. Too many points.

Pick: Lions +4.5

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