Atlanta (3-2) at San Francisco (4-2)
When: Sunday, October 19th 2025
Where: Levi’s Stadium,
Santa Clara, CA
Time: 8:20 ET | TV: NBC
Opening Odds: San Francisco -3.5/45.5
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Falcons vs 49ers Recent Meetings
Prediction
The 49ers continue to battle through injuries and will take on a hot Atlanta team coming off a Monday night win. San Fran lost defensive stud Fred Warner for the season last week, but the offense gets a boost this week with the return of tight end George Kittle. Brock Purdy is still out, but Mac Jones has filled in admirably. The Falcons ruled out five players for this week, including four on defense. The 49ers should have success moving the ball and getting past the Falcons.
Pick: 49ers -2
