Dodgers vs Cubs Odds and Free Prediction [4/22/25]

LA Dodgers (16-7) at Chicago Cubs (14-10)
When: Tuesday, April 22nd 2025
Where: Wrigley Field,
Chicago, IL

Time: 7:40 ET | TV: MLB.tv
Opening Odds: Los Angeles -109

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Dodgers vs Cubs Recent Meetings

DateHome/AwayH StarterA StarterLineO/U
4/13/25LAD 2 - CHC 4T. GlasnowC. Rea-219/9U
4/12/25LAD 0 - CHC 16R. SasakiB. Brown-172/9O
4/11/25LAD 3 - CHC 0Y. YamamotoM. Boyd-170/8.5U
3/19/25CHC 3 - LAD 6J. SteeleR. Sasaki126/7.5O
3/18/25CHC 1 - LAD 4S. ImanagaY. Yamamoto140/8U
2024 Season
9/11/24LAD 10 - CHC 8B. MillerJ. Wicks-153/9O
9/10/24LAD 3 - CHC 6Y. YamamotoS. Imanaga-142/8O
9/9/24LAD 4 - CHC 10W. BuehlerK. Hendricks-185/10O
4/7/24CHC 8 - LAD 1S. ImanagaG. Stone-101/8.5O
4/6/24CHC 1 - LAD 4J. WicksY. Yamamoto134/7.5U
4/5/24CHC 9 - LAD 7K. HendricksB. Miller164/7.5O
2023 Season
4/23/23CHC 3 - LAD 7M. StromanC. Kershaw127/7.5O
4/22/23CHC 4 - LAD 9H. WesneskiD. May111/8.5O
4/21/23CHC 13 - LAD 0D. SmylyJ. Urias148/9.5O
4/20/23CHC 2 - LAD 6J. AssadM. Grove-105/11.5U
4/16/23LAD 2 - CHC 3J. UriasD. Smyly-224/8U
4/15/23LAD 2 - CHC 1M. GroveJ. Taillon-145/8.5U
4/14/23LAD 2 - CHC 8N. SyndergaardJ. Steele-154/8.5O
2022 Season
7/10/22LAD 11 - CHC 9J. UriasD. Smyly-260/8O
7/9/22LAD 4 - CHC 2C. KershawM. Stroman-248/7.5U
Courtesy of Don Best Sports

Dustin May L10 Starts

DatevsS/RResScoreIPHRERKBBHRPP/IPGB:FB
4/14/25COLSW5-36.03117007612.74.00
4/7/25@ WASSL4-66.03311308614.32.50
4/1/25ATLSND3-15.01106308116.23.00
5/17/23MINSND7-31.01002001616.0.00
5/12/23SDSND4-26.25223109013.53.67
5/6/23@ SDSW2-16.03006109916.51.00
4/28/23STLSW7-35.032244010420.81.00
4/22/23@ CHCSW9-45.12226309618.0.80
4/17/23NYMSND6-85.28551018715.42.25
4/11/23@ SFSL0-55.12223407714.41.00
Courtesy of Don Best Sports

Shota Imanaga L10 Starts

DatevsS/RResScoreIPHRERKBBHRPP/IPGB:FB
4/15/25@ SDSND2-15.04107319318.6.50
4/9/25TEXSL2-65.07554127615.2.40
4/4/25SDSW3-17.14114019112.41.67
3/29/25@ AZSW4-37.03114209113.01.14
3/18/25LADSND1-44.00002406917.2.67
9/22/24WASSW5-07.06004009413.45.00
9/16/24ATHSW9-26.052211319916.54.00
9/10/24@ LADSW6-37.07334038912.71.00
9/4/24PITSW12-07.00007209513.62.00
8/30/24@ WASSW7-66.04338119616.0.80
Courtesy of Don Best Sports


Prediction

These teams have already met five times this season and could see each other again in October. L.A. took the first three, while Chicago battled back to take the last two, including a 16-0 win. I like Chicago in this one. The Dodgers are just 6-5 on the road this season and they struggle against left-handed pitching. L.A. is hitting .194 against southpaws on the season and .176 away from home. In three career starts against L.A., Imanaga has allowed just three earned runs over 15 innings. I think he can keep the Dodger bats quiet in the series opener.

Pick: Cubs +108

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