Chiefs vs Chargers Odds and Free Prediction [9/5/25]

Kansas City (0-0) vs LA Chargers (0-0)
When: Friday, September 5th 2025
Where: Corinthians Arena,
Sao Paulo, Brazil

Time: 8:00 ET | TV: YouTube
Opening Odds: Kansas City -3/46.5

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Chiefs vs Chargers Recent Meetings

DateAway/HomeLineATSTotRusPasTotRusPas
12/8/24LAC (17) - KC (19)-4.5/42.5LAC/U2989620228894194
9/29/24KC (17) - LAC (10)6.5/42KC/U32910122822455169
1/7/24KC (13) - LAC (12)-3/35.5KC/U268123145353118235
10/22/23LAC (17) - KC (31)-6/48.5KC/U48368415358139219
11/20/22KC (30) - LAC (27)5.5/52.5LAC/O485163322365115250
9/15/22LAC (24) - KC (27)-4/53LAC/U3199322640175326
12/16/21KC (34) - LAC (28)3/54.5KC/O49686410428192236
9/26/21LAC (30) - KC (24)-6.5/55LAC/U43718625135277275
1/3/21LAC (38) - KC (21)7/43LAC/O26851217416135281
9/20/20KC (23) - LAC (20)8.5/47LAC/U414125289479183296
Courtesy of Don Best Sports

Chiefs Injury Report

Player Status/Updated
Omarr Norman-LottDTQues Sept. 5 - Ankle - 8/19/25
Jack CochraneLBQues Sep. 5th - Knee - 8/16/25
Nohl WilliamsDBQues Sept 5 - Concussion - 8/16/25
Kareem HuntRBQues Sept. 5 - Quadricep - 8/13/25
Janarius RobinsonDEQues Sept 5 - Foot - 8/11/25
Jaylen WatsonCBQues Sept. 5 - Concussion - 8/10/25
Brashard SmithRBQues Sep. 5th - Finger - 8/7/25
Drue TranquillLBQues Sep. 5th - Back - 8/2/25
Jared WileyTEQues Sep. 5th - Hamstring - 8/2/25
Xavier WorthyWRQues Sept. 5 - Head - 7/29/25
Hollywood BrownWRQues Sept. 5 - Ankle - 7/29/25
Jalen RoyalsWROut Fri - Knee - 9/3/25
Rashee RiceWRMid Oct - Suspension - 8/27/25
Jake BriningstoolTEOut indefinitely - Hamstring - 8/28/25
Ethan DriskellOTOut indefinitely - Appendix - 8/28/25
Brandon GeorgeLBout for season - Undisclosed - 8/27/25
Nazeeh JohnsonSOut indefinitely - Shoulder - 8/28/25
Felix Anudike-UzomahDEOut indefinitely - Hamstring - 8/19/25
Deon BushSout for season - Hamstring - 8/12/25
Kristian FultonCBOut indefinitely - Knee - 8/12/25
Jawaan TaylorOTOut indefinitely - Undisclosed - 7/24/25
Courtesy of Don Best Sports

Chargers Injury Report

Player Status/Updated
Elijah MoldenDBQues Fri - Knee - 9/2/25
Quentin JohnstonWRQues Sep. 5th - Concussion - 8/17/25
Trey LanceQBQues Sept 5 - Hand - 8/13/25
Mekhi BectonGQues Sept. 5 - Undisclosed - 8/5/25
Otito OgbonniaDLQues Sept. 5 - Undisclosed - 8/3/25
Ladd McConkeyWRQues Sep. 5 - Undisclosed - 7/30/25
Cam HartCBQues Sept. 5 - Shoulder - 7/24/25
Ja'Sir TaylorDBQues Sept. 5 - Ribs - 7/24/25
Josh HarrisLSOut indefinitely - Undisclosed - 8/28/25
Josh FugaDLout for season - Undisclosed - 8/27/25
Jordan OladokunCBout for season - Undisclosed - 8/27/25
Junior ColsonLBOut Indefinitely - Shoulder - 8/27/25
Tre HarrisWRQues Sept. 5 - Undisclosed - 8/28/25
Deane LeonardDBOut indefinitely - Leg - 8/28/25
Eric RogersCBOut indefinitely - Undisclosed - 8/28/25
Rashawn SlaterOTout for season - Knee - 8/10/25
Savion WashingtonOTQues Sep. 5 - Undisclosed - 7/29/25
Najee HarrisRBQues Sep. 5 - Eye - 7/29/25
Courtesy of Don Best Sports


Prediction

The Chargers have played the Chiefs well recently, but the end result has been the same. L.A. has held the Chiefs to under 20 points in each of the last three meetings only to come up short each time. I expect bigger things from the Chargers this season and they can do it with defense and Justin Herbert. L.A. also bulked up their running game to take some pressure off Herbert. The Chiefs are still the kings of the AFC West, but the gap is closing.

Pick: Chargers +3

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