Buffalo (7-3) at Houston (5-5)
When: Thursday, November 20th 2025
Where: NRG Stadium,
Houston, TX
Time: 8:15 ET | TV: Prime
Opening Odds: Buffalo -2.5/43
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Bills vs Texans Recent Meetings
Prediction
I’m going to take the points here. Houston had an awful start to the season, but have now turned things around, going 3-1 over their last four to get back into playoff conversation. The Bills meanwhile, have sputtered since their 4-0 start, posting just a 3-3 mark since. Buffalo’s offense was great last week, but will struggle to score against a Houston defense that is elite and allows just 16.3 points a game. If there’s one thing you can do against the Buffalo defense and that is run the ball. The Bills have surrendered 17 rushing scores this season and allowed 145 rushing yards to the Bucs last week, before contact. Buffalo may get a W here, but it won’t be easy.
Pick: Texans +6
