Bears vs 49ers Odds, Stats and Free Pick [12/28/25]

Chicago (11-4) at San Francisco (11-4)
When: Sunday, December 28th 2025
Where: Levi’s Stadium,
Santa Clara, CA

Time: 8:20 ET | TV: NBC
Opening Odds: San Francisco -3/50.5

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Bears vs 49ers Recent Meetings

Courtesy of Covers.com
Courtesy of Covers.com
Courtesy of Covers.com



Prediction

The 49ers may be banged up but they’re still finding ways to win games. Monday night’s blowout in Indianapolis was impressive, as Brock Purdy passed for five touchdown passes and has this offense rolling. San Fran has scored 26 or more in three straight games. In come the Bears, who could be the most surprising team of the NFL season. Chicago could have the division wrapped-up by game time if the Packers lose to the Ravens. The 49ers routed the Bears last season and sacked Caleb Williams seven times. I trust Purdy in this one more than I do the young Williams. I like the Niners at home.

Pick: 49ers -3

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