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**All plays are Listed Pitchers and trends are through 4/21/25**
St Louis (Mikolas) at Atlanta (Elder) – 12:15 ET
STL are 1-10 in their last 11 road games.
STL are 8-1 in their last 9 Wed. games.
Under is 6-2 in STL last 8 Wed. games.
Under is 7-2 in ATL last 9 Wed. games.
Over is 6-2-2 in ATL last 10 overall.
Under is 39-15-2 in ATL last 56 home games.
Pick: Cardinals +143
Cincinnati (Singer) at Miami (Alcantara) – 1:10 ET
CIN are 7-15 in their last 22 games as an underdog.
Over is 37-14-3 in MIA last 54 home games.
MIA are 8-17 in their last 25 games as a favorite.
Over is 7-3-1 in Alcantara’s last 11 home starts.
Pick: Marlins -120
Philadelphia (Wheeler) at NY Mets (Peterson) – 1:10 ET
Over is 8-0 in PHI last 8 on grass.
Over is 8-0 in PHI last 8 overall.
Under is 7-2-1 in PHI last 10 Wed. games.
NYM are 46-15 in their last 61 home games.
Over is 21-9-1 in NYM last 31 Wed. games.
Over is 11-1 in Peterson’s last 12 Wed. starts.
PHI are 2-6 in Wheeler’s last 8 starts vs. NYM.
PHI are 7-19 in the last 26 meetings in New York.
Pick: Mets +100
LA Dodgers (Casparius) at Chicago Cubs (Boyd) – 7:00 ET
LAD are 12-1 in their last 13 Wed. games.
Over is 19-6-1 in LAD last 26 Wed. games.
LAD are 38-15 in their last 53 overall.
Over is 9-1 in CHC last 10 Wed. games.
Over is 6-1-1 in CHC last 8 home games.
Over is 11-3-1 in the last 15 meetings in Chicago.
LAD are 9-3 in the last 12 meetings in Chicago.
Pick: Cubs -124
Milwaukee (Peralta) at San Francisco (Webb) – 9:45 ET
MIL are 20-8 in their last 28 Wed. games.
Over is 9-3 in SF last 12 overall.
SF are 9-3 in their last 12 games as a favorite.
Over is 9-3 in SF last 12 on grass.
Pick: Giants -1.5 +160
NY Yankees (Rodon) at Cleveland (Ortiz) – 1:10 ET
NYY are 6-2 in their last 8 overall.
NYY are 6-2 in their last 8 games on grass.
Under is 5-2-1 in NYY last 8 overall.
Over is 8-2-1 in the last 11 meetings.
NYY are 15-7 in the last 22 meetings in Cleveland.
Pick: Guardians +131
Seattle (Hancock) at Boston (Newcomb) – 6:45 ET
SEA are 8-2 in their last 10 overall.
Over is 38-15-5 in SEA last 58 road games.
Over is 7-3 in SEA last 10 overall.
Under is 5-2-1 in BOS last 8 home games.
Under is 7-3-1 in BOS last 11 games as a favorite.
Over is 27-7 in the last 34 meetings.
Over is 25-9-1 in the last 35 meetings in Boston.
Pick: Mariners +120
Toronto (Francis) at Houston (Gusto) – 7:40 ET
Under is 21-6-1 in TOR last 28 road games.
Under is 21-8-1 in TOR last 30 on grass.
TOR are 5-12 in their last 17 road games.
HOU are 0-8 in their last 8 Wed. games.
Under is 8-3 in the last 11 meetings.
Pick: Blue Jays -108
Chicago White Sox (Wilson) at Minnesota (Festa) – 7:40 ET
CHW are 19-72 in their last 91 road games.
CHW are 19-71 in their last 90 overall.
CHW are 19-71 in their last 90 games on grass.
Under is 9-3-1 in MIN last 13 overall.
Under is 9-3-1 in MIN last 13 on grass.
MIN are 15-36 in their last 51 games on grass.
CHW are 16-36 in the last 52 meetings.
Pick: White Sox +1.5 +106
Texas (Rocker) at Athletics (Sears) – 10:05 ET
TEX are 25-10 in their last 35 Wed. games.
Over is 32-15-5 in TEX last 52 road games.
Over is 8-2 in ATH last 10 games as a home underdog.
ATH are 2-7 in their last 9 home games.
ATH are 7-16 in their last 23 games as an underdog.
ATH are 6-2 in Sears’ last 8 starts vs. TEX.
Pick: Rangers -103
San Diego (Hart) at Detroit (Olson) – 1:10 ET
SD are 10-4 in their last 14 interleague games.
SD are 63-29 in their last 92 overall.
SD are 61-28 in their last 89 games on grass.
DET are 2-6 in their last 8 interleague games.
DET are 20-7 in their last 27 home games.
Under is 24-9-3 in DET last 36 home games.
Over is 7-3-2 in the last 12 meetings.
SD are 3-7 in the last 10 meetings in Detroit.
Pick: Padres +135
Baltimore (Sugano) at Washington (Williams) – 6:45 ET
Over is 10-1-1 in BAL last 12 games as a favorite.
BAL are 2-8 in their last 10 Wed. games.
Over is 23-9-3 in BAL last 35 overall.
Under is 9-1 in WAS last 10 interleague games.
Under is 8-2 in WAS last 10 Wed. games.
WAS are 12-5 in Williams’ last 17 starts on grass.
BAL are 9-2 in the last 11 meetings.
Under is 25-10 in the last 35 meetings.
Pick: Nationals +120
Colorado (Marquez) at Kansas City (Lorenzen) – 7:40 ET
COL are 27-89 in their last 116 road games.
COL are 13-42 in their last 55 Wed. games.
Under is 6-2 in COL last 8 overall.
Over is 8-2 in KC last 10 interleague home games.
Under is 37-14-2 in KC last 53 overall.
Under is 37-14-2 in KC last 53 on grass.
Pick: Royals -1.5 +104
Pittsburgh (Heaney) at LA Angels (Kochanowicz) – 9:38 ET
PIT are 10-26 in their last 36 road games.
Under is 7-3-1 in PIT last 11 overall.
Under is 7-3-1 in PIT last 11 on grass.
Under is 8-2 in LAA last 10 games as a favorite.
LAA are 7-17 in their last 24 games as a favorite.
Under is 7-3-1 in Kochanowicz’s last 11 on grass.
Over is 10-2-1 in the last 13 meetings.
Pick: Pirates +131
Tampa Bay (Bradley) at Arizona (Rodriguez) – 9:40 ET
TB are 1-7 in their last 8 games as an underdog.
TB are 3-13 in their last 16 Wed. games.
Under is 35-16-3 in TB last 54 on grass.
AZ are 8-2 in their last 10 interleague home games.
AZ are 7-2 in their last 9 vs. American League East.
AZ are 7-2 in their last 9 interleague games.
Pick: Rays +126