Titans vs Bills Preview & Free Pick [September 19th 2022]

The first of two Monday Night games has the Bills hosting the Titans

Tennessee (0-1) at Buffalo (1-0)
When: Monday, September 19th 2022
Where: Highmark Stadium,
Orchard Park, NY
Time: 7:15 ET | TV: ESPN
Opening Odds: Buffalo -7/51.5

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The Buffalo Bills will open the home part of their 2022 schedule on Monday Night Football against a team that has had their number each of the last two seasons. The Tennessee Titans come to town looking for a third consecutive win over this year’s Super Bowl favorites. Tennessee dominated the Bills 42-16 in Week 5 of the 2020 season and rallied for a 34-31 victory in Week 6 last season on a Monday night. Both those games were in Nashville, so this stage will be different. Buffalo led 31-24 entering the fourth quarter last season before the Titans scored 10 fourth-quarter points. Derrick Henry was a monster, running for 143 yards and three scores, including the game-winner with 3:05 left.

Josh Allen tossed three touchdown passes and 353 yards and was picked off once. Allen threw for 297 yards and three scores, while rushing for 56 yards in last week’s impressive 31-10 win at the L.A. Rams to open the 2022 NFL season. Buffalo scored 21 unanswered second-half points in defeating the defending Super Bowl champions. The Titans are looking to bounce back from a 21-20 home loss to the New York Giants in Week 1 after they led by 13 points at halftime. Even though Tennessee has beaten Buffalo the last two seasons, they come into this contest as 10-point underdogs with a total of 47.5. The underdog in this series is 10-1 ATS in the last 11.


Tennessee lost last week to the Giants as 5.5-point favorites despite Ryan Tannehill throwing for two touchdowns and zero interceptions on 20-of-33 completions. The problem offensively was Henry, who was held to just 82 rushing yards on 21 carries. Tannehill will need to open up the passing game to get more lanes for Henry against a solid Buffalo defense. On Saturday, the Titans ruled out cornerback Kristian Fulton (hamstring), running back Dontrell Hilliard (hamstring) and offensive lineman Jamarco Jones (elbow). Wide receiver Kyle Philips (shoulder) is listed as questionable for Monday’s game. The Titans are 4-1 against the spread in their last five games after a straight-up loss and 8-2 ATS in their last 10 Monday games.


Allen and the Bills made a huge statement in Week 1 and so far are proving why they should be Super Bowl favorites. Allen was 26-of-31 for 297 passing yards and three touchdowns, but was also intercepted twice. Buffalo’s defense was impressive with seven sacks and three interceptions. Eight-time Pro Bowl linebacker Von Miller made his Bills debut and recorded two sacks and three tackles for loss against the Rams. It was the 21st time Miller has recorded at least two sacks in a game. Defensive tackle Ed Oliver (ankle) didn’t practice Thursday and was ruled out. The Bills also listed wide receiver Gabe Davis (ankle) and cornerback Dane Jackson (knee) as questionable. The Bills are 4-0-1 against the spread in their last five games as a favorite, including last week’s cover.

The Bills are probably the best team in the league, but Tennessee isn’t a pushover. I’m not going to overreact to them losing to the Giants. Henry and the Titans usually step up under the bright lights and they do seem to have Buffalo’s number. The dog in this series has covered 10 of the last 11. I’ll take the points.

Week 2 NFL Staff Selections

Pick: Titans +10