Chiefs vs Giants Odds and Free Prediction [9/21/25]

Kansas City (0-2) at NY Giants (0-2)
When: Sunday, September 21st 2025
Where: MetLife Stadium,
East Rutherford, NJ

Time: 8:20 ET | TV: NBC
Opening Odds: Kansas City -6.5/43

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Chiefs vs Giants Recent Meetings

DateAway/HomeLineATSTotRusPasTotRusPas
11/1/21NYG (17) - KC (20)-10.5/53NYG/U36810726130072228
11/19/17KC (9) - NYG (12)10/44.5NYG/U363134229317112205
9/29/13NYG (7) - KC (31)-3.5/43.5KC/U39010228829898200
10/4/09NYG (27) - KC (16)9/43NYG/P21212488429156273
8/17/06KC (0) - NYG (17)-3/35NYG/U1114071309154155
12/17/05KC (17) - NYG (27)-2.5/48NYG/U362188174406223183
8/13/04KC (24) - NYG (34)-3/34NYG/O461100361331185146
9/23/01NYG (13) - KC (3)1/39NYG/U8888089890
12/20/98KC (7) - NYG (28)-1.5/37.5NYG/U27966213309160149
9/10/95NYG (17) - KC (20)-7/37.5NYG/U000000
Courtesy of Don Best Sports

Chiefs Injury Report

Player Status/Updated
Jalen RoyalsWRQues Sept. 21 - Knee - 9/14/25
Janarius RobinsonDEQues Sept. 21 - Foot - 9/14/25
Jared WileyTEQues Sept. 21 - Hamstring - 9/14/25
Jawaan TaylorOTQues Sept 21 - Knee - 9/18/25
Kristian FultonCBOut Sept 21 - Ankle - 9/19/25
Mike DannaDEOut Sept. 21 - Quadricep - 9/19/25
Xavier WorthyWROut indefinitely - Shoulder - 9/8/25
Rashee RiceWRMid Oct - Suspension - 8/27/25
Jake BriningstoolTEOut indefinitely - Hamstring - 8/28/25
Ethan DriskellOTOut indefinitely - Appendix - 8/28/25
Brandon GeorgeLBout for season - Undisclosed - 8/27/25
Nazeeh JohnsonSOut indefinitely - Shoulder - 8/28/25
Felix Anudike-UzomahDEOut indefinitely - Hamstring - 8/19/25
Deon BushSout for season - Hamstring - 8/12/25
Courtesy of Don Best Sports

Giants Injury Report

Player Status/Updated
Tyrone Tracy Jr.RBQues Sun - Calf - 9/18/25
Darius SlaytonWRQues Sept. 21 - Groin - 9/18/25
Wan'Dale RobinsonWRQues Sept. 21 - Foot - 9/18/25
Chris BoardLBQues Sept 21 - Chest - 9/17/25
Demetrius Flannigan-FowlesLBQues Sept. 21 - Calf - 9/14/25
Rakeem Nunez-RochesDLQues Sept. 21 - Foot - 9/14/25
Micah McFaddenLBQues Sept. 21 - Leg - 9/14/25
TJ MooreCBQues Sept. 21 - Leg - 9/14/25
Chris ManhertzTEQues Sept. 21 - Undisclosed - 9/14/25
Thomas Fidone IITEQues Sept. 21 - Undisclosed - 9/14/25
Bryce Ford-WheatonWRQues Sept. 21 - Achilles - 9/14/25
D.J. DavidsonDLQues Sept. 21 - Seizure - 9/14/25
Jon RunyanGQues Sept. 21 - Ankle - 9/14/25
Jalin HyattWRQues Sept. 21 - Leg - 9/14/25
Darius MuasauLBOut Sun - Head - 9/20/25
Anthony Johnson Jr.SOut indefinitely - Undisclosed - 9/4/25
Rico PaytonCBOut indefinitely - Undisclosed - 8/29/25
Joshua EzeuduGOut indefinitely - Undisclosed - 8/28/25
Eric GrayRBOut indefinitely - Undisclosed - 8/28/25
Victor DimukejeLBOut indefinitely - Pectoral - 8/28/25
Andrew ThomasOTOut indefinitely - Foot - 9/14/25
Courtesy of Don Best Sports


Prediction

Both teams are 0-2 and can’t afford to lose another game this early in the season or they can almost forget about the playoffs. If there’s one game that can get Kansas City right again, it’s playing the Giants. New York’s defense has not improved from last season and that was evident last week against Dallas. In their last six games dating back to last season, the Giants have allowed at least 20 points in all six and at least 34 points in four of those. The Chiefs are due for a breakout game and an easy opponent. They have played some stiff competition since the start of the playoffs last season and despite losing to the Eagle last week, played solid defense. Xavier Worthy is back at practice this week and that would be a huge addition to this offense. I can see this one getting ugly and I like the Chiefs to roll. I’ll lay the 6 points on Sunday night.

Pick: Chiefs -6

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