Kansas City (5-3) at Buffalo (5-2)
When: Sunday, November 2nd 2025
Where: Highmark Stadium,
Orchard Park, NY
Time: 4:25 ET | TV: CBS
Opening Odds: Kansas City -1.5/51.5
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Chiefs vs Bills Recent Meetings
Prediction
It’s quite simple: The Chiefs beat the Bills in the playoffs every time, while Buffalo dominates the regular season matchups. Kansas City has been on a roll lately, winning three in a row – all at home – but now go on the road for their toughest test to date. The Chiefs have already lost two road games, including their last one at Jacksonville. The Bills are 3-1 at home and have scored at least 30 points in all three of their victories. It’s another game that Buffalo really wants to win and I say they get it.
Pick: Bills +2
