Louisville (0-0) at Ole Miss (0-0)
When: Sunday, September 6th 2026
Where: Vaught Hemingway Stadium,
Oxford, MS
Time: 7:30 ET | TV: ABC
Opening Odds: Mississippi -6.5/55.5
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Louisville vs Ole Miss Recent Meetings
Prediction
The post-Lane Kiffin era begins in Oxford, as the Ole Miss Rebels host Louisville on Sunday night in the lone top-25 game of the weekend. Yes, the Rebels should be a high-scoring team again, but don’t discount the Cardinals defense, which ranked 16th nationally last year and return key starters. They should be able to slow down Ole Miss enough to keep this close. Louisville still has two explosive running backs to take pressure off new quarterback Lincoln Kienholz.
Pick: Louisville +6.5
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