Detroit (1-0) at Buffalo (1-0)
When: Thursday, September 17th 2026
Where: Highmark Stadium,
Buffalo, NY
Time: 8:15 ET | TV: Prime
Opening Odds: Buffalo -3/52
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Lions vs Bills Recent Meetings
Prediction
Both teams survived their season openers in much the same way – prolific offense and sketchy defense. The last time these two played it was 48-42. All signs point to the over in the first game at Buffalo’s new stadium. I don’t see either team being able to slow the other down and I think this game comes down to the wire. Let’s do a teaser here.
Pick: Lions +11 and Over 48
