Guardians vs White Sox Starters and Free Prediction [6/22/26]

Cleveland (41-37) at Chicago White Sox (39-37)
When: Monday, June 22nd 2026
Where: Rate Field,
Chicago, IL

Time: 7:40 ET | TV: mlb.tv
Opening Odds: Chicago -105/8

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Guardians vs White Sox Recent Meetings

Courtesy of Covers.com
Courtesy of Covers.com
Courtesy of Covers.com


Prediction

For the first time this season, the Guardians and White Sox will meet up with first place on the line in the AL Central. Cleveland currently holds the slim lead thanks to the White Sox recent woes. Chicago has lost five of their last six games and the offense has hit the skids. That’s not good when facing Williams, who can be dominate at times. He was rocked by a good Milwaukee team in his last outing, but I expect a bounce back from him. Kay had a good May, but June has been unkind to him so far. I like Cleveland to take the opener.

Pick: Guardians -107

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