Washington (1-3-1) at San Francisco (5-0)
When: Monday, October 19th 2026
Where: Levi’s Stadium,
Santa Clara, CA
Time: 8:15 ET | TV: ESPN
Opening Odds: San Francisco -7.5/49.5
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Commanders vs 49ers Recent Meetings
Prediction
San Francisco has been very impressive so far in 2026 and I don’t see them losing this game. Of course, it’s the NFL and anything can happen. Just look what happened to the Rams yesterday. Still, the 49ers are the best team in the NFC right now and the Commanders are horrible. I’m not afraid to lay this many points.
Pick: 49ers -7.5
